Cells Aging and Human Disease

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease.

Cells  Aging  and Human Disease

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both breaking research and current state-of-the-art clinical interventions in aging and age-related disease. Far from merely sharing a common onset late in the lifespan, age-related diseases are linked by fundamental common characteristics at the genetic and cellular levels. Emphasizing human cell mechanisms, the first section presents and analyzes our current knowledege of telomere biology and cell senescence. In superb academic detail, the text brings the reader up to date on telomere maintenance, telomerase dynamics, and current research on cell senescence--and the general model--cell senescence as the central component in human senescence and cancer. For each human malignancy, the chapter reviews and analyzes all available data on telomeres and telomerase, as well as summarizing current work on their clinical application in both diagnosis and cancer therapy. The second edition, oriented by organs and tissues, explores the actual physiological impact of cell senescence and aging on clinical disease. After a summary of the literature on early aging syndromes--the progerias--the text reviews aging diseases (Alzheimer's dementia, osteoarthritis, atherosclerosis, immune aging, presbyopia, sarcopenia, etc.) in the context of the tissues in which they occur. Each of the ten clinical chapters--skin, cardiovascular system, bone and joints, hematopoetic and immune systems, endocrine, CNS, renal, muscle, GI, and eyes--examines what we know of their pathology, the role of cell sensescence, and medical interventions, both current and potential.

More Books:

Cells, Aging, and Human Disease
Language: en
Pages: 504
Authors: Michael B. Fossel M.D.
Categories: Medical
Type: BOOK - Published: 2004-06-10 - Publisher: Oxford University Press

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both
Cells, Aging, and Human Disease
Language: en
Pages: 504
Authors: Michael B. Fossel M.D.
Categories: Science
Type: BOOK - Published: 2004-06-10 - Publisher: Oxford University Press

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to clinical application, analyzing the fundamental cellular changes which underlie human age-related disease. With over 4,000 references, this text explores both the fundamental processes of human aging and the tissue-by-tissue pathology, detailing both
Cells, Aging, and Human Disease
Language: en
Pages: 489
Authors: Michael Fossel
Categories: Family & Relationships
Type: BOOK - Published: 2004 - Publisher: Oxford University Press on Demand

It explains both the limited and general model of cell senescence as the central component in human clinical aging."--BOOK JACKET.
The Telomerase Revolution
Language: en
Pages: 256
Authors: Michael Fossel
Categories: Medical
Type: BOOK - Published: 2015-10-06 - Publisher: BenBella Books, Inc.

One of Wall Street Journal's "Best Books for Science Lovers" in 2015 Science is on the cusp of a revolutionary breakthrough. We now understand more about aging—and how to prevent and reverse it—than ever before. In recent years, our understanding of the nature of aging has grown exponentially, and dramatic
The Telomerase Revolution
Language: en
Pages: 240
Authors: Michael Fossel
Categories: Health & Fitness
Type: BOOK - Published: 2016-02-01 - Publisher:

We are at the beginning of a new scientific revolution. Dramatic life extension - even age reversal - has moved from science fiction to real possibility. The Telomerase Revolution reveals the latest research on human ageing and the enzyme telomerase which is starting to be used to slow the rate